منابع مشابه
Improving drug safety surveillance: lessons from rosiglitazone.
The thiazolidinediones (TZDs) were introduced to the US market in 1997 as therapies to control hyperglycemia in patients with diabetes mellitus. This class of drugs (agonists of peroxisome proliferator-activated receptor ) has a wide range of biochemical effects, including lowering blood sugar by increasing insulin sensitivity. The TZDs were adopted relatively rapidly and achieved sales of near...
متن کاملImproving drug safety monitoring.
Drug safety monitoring is important in children. Young age, polypharmacy, prolonged hospitaliza-tion, being critically ill and use of unlicensed and off-label drugs have been identified as risk factors which predispose a child to experience an adverse drug reaction. In our country, the HIV/AIDS epidemic, setting up of intensive care units, increasing availability of imaging studies, and the int...
متن کاملSystems pharmacology augments drug safety surveillance
Small molecule drugs are the foundation of modern medical practice, yet their use is limited by the onset of unexpected and severe adverse events (AEs). Regulatory agencies rely on postmarketing surveillance to monitor safety once drugs are approved for clinical use. Despite advances in pharmacovigilance methods that address issues of confounding bias, clinical data of AEs are inherently noisy....
متن کاملImproving drug safety: a joint responsibility.
Over the past decades, health care delivery has become more complex, and the traditional roles and relationships that structure this process have altered to allow new decision makers to enter the arena. Responsibility for drug safety, previously perceived by the public as belonging to regulatory bodies and physicians, has, in their eyes, now extended to the manufacturer. Increasingly, benefits ...
متن کاملImproving Assessment of Drug Safety Through Proteomics
BACKGROUND Early detection of adverse effects of novel therapies and understanding of their mechanisms could improve the safety and efficiency of drug development. We have retrospectively applied large-scale proteomics to blood samples from ILLUMINATE (Investigation of Lipid Level Management to Understand its Impact in Atherosclerotic Events), a trial of torcetrapib (a cholesterol ester transfe...
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ژورنال
عنوان ژورنال: Circulation: Cardiovascular Quality and Outcomes
سال: 2010
ISSN: 1941-7713,1941-7705
DOI: 10.1161/circoutcomes.110.958413